4-Toluenesulfonyl chloride → 4H-Thieno[2,3-c]furan-6-one
反応式
O[CH2:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]([OH:10])=[O:9].C1(C)C=CC(S(Cl)(=O)=O)=CC=1>ClCCl>[S:5]1[C:4]2[C:8](=[O:9])[O:10][CH2:2][C:3]=2[CH:7]=[CH:6]1参加物
4
実験手順
A solution of 3-hydroxymethyl-thiophene-2-carboxylic acid (25 mg, 0.15 mmol) in dichloromethane (4 ml) and triethylamide (1.5 mL) is treated with p-toluenesulfonyl chloride (50 mg, 0.26 mmol) and the reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the product is purified by chromatography (silica gel, ethylacetate/hexane) to give the title compound. This material was used directly in the preparation of Example 70.
後処理
- concentrationThe reaction mixture is concentrated
- customthe product is purified by chromatography (silica gel, ethylacetate/hexane)
出典と根拠
- ORDレコード
- ord-4656d918e5db44528d2643027bb0f2b0
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08455535B2
反応ノート
読み込み中…