Picolinate → Methyl 5-(4-Ethylphenyl)-6-(pyridin-4-yl)pyridine-2-carboxylate

HRID 12542ノート

反応式

HRID 12542 の反応式
N1C=CC=CC=1C([O-])=O.[CH2:10]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:29]3[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=3)=[N:20][C:21]([C:24]([O:26][CH2:27]C)=[O:25])=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH3:11]>OS(O)(=O)=O.CO>[CH2:10]([C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([O:26][CH3:27])=[O:25])=[N:20][C:19]=2[C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)=[CH:16][CH:17]=1)[CH3:11]

参加物

5

反応物 2

HCID 6920223PicolinateHCID 68408497Ethyl 3-(4-Ethylphenyl)-[2,4']-bipyridinyl-6-carboxylate

生成物 1

HCID 24752879Methyl 5-(4-Ethylphenyl)-6-(pyridin-4-yl)pyridine-2-carboxylate

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 887Methanol溶媒

実験手順

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(pyridine-4-yl)phenyl)pyridine-2-carboxylate (Compound 49, 48 mg, 0.14 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-36fda2b6e6234cea9f29b13440c68cbc
出典データセット
uspto-grants-2010_06
特許番号
US07728014B2

反応ノート

読み込み中…