(S)-N-Cbz-1,1-diethoxypropan-2-amine → (2S)-1,1-Diethoxy-2-propanamine

HRID 1254487ノート

反応式

HRID 1254487 の反応式
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH:7]C(=O)OCC1C=CC=CC=1)[CH3:6])[CH3:2]>CO>[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH2:7])[CH3:6])[CH3:2]

参加物

3

反応物 1

HCID 86652567(S)-N-Cbz-1,1-diethoxypropan-2-amine

生成物 1

HCID 12398111(2S)-1,1-Diethoxy-2-propanamine収率 100.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To the solution of (S)-benzyl 1,1-diethoxypropan-2-ylcarbamate 844 mg (3.00 mmol) in methanol 50 ml, 5% palladium on carbon 30 mg was added and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered on celite and washed with methanol 200 ml and the mother solution was concentrated in vacuo to obtain the title compound 442 mg (100%).

後処理

  1. filtrationThe reaction mixture was filtered on celite
  2. washwashed with methanol 200 ml
  3. concentrationthe mother solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-75d9869761dd4da4a9e78290eb8f57e3
出典データセット
uspto-grants-2013_06
特許番号
US08455488B2

反応ノート

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