Diisobutylaluminum hydride → 5-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde

HRID 12545

反応式

HRID 12545 の反応式
[C:1]1([C:7]2[N:12]=[C:11]([C:13](OCC)=[O:14])[CH:10]=[CH:9][C:8]=2[C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C[AlH]CC(C)C)C>C(Cl)Cl>[F:26][C:24]([F:25])([F:27])[C:21]1[CH:20]=[CH:19][C:18]([C:8]2[CH:9]=[CH:10][C:11]([CH:13]=[O:14])=[N:12][C:7]=2[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:23][CH:22]=1

参加物

4

反応物 2

HCID 14487Diisobutylaluminum hydrideHCID 68408073Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate2 回

生成物 1

HCID 866190715-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Following General Procedure L, ethyl 5-(4-trifluoromethylphenyl)-6-phenylpyridine-2-carboxylate (Compound 25, 74 mg, 0.20 mmol) and DIBAL-H (0.3 ml, 0.30 mmol, 1.0 M in hexane) in CH2Cl2 (3 ml) were reacted to produce the title compound after purification by column chromatography (silica gel, 15% ethyl acetate in hexane).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-25cfcf96b25d4fc6b54c9b584a00826c
出典データセット
uspto-grants-2010_06
特許番号
US07728014B2

関連ノート

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