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3-Aminopropylphosphonic acid → (3-{[6-Phenyl-5-(4-trifluoromethylphenyl)-pyridin-2-ylmethyl]-amino}-propyl)-phosphonic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopropylphosphonic acid | HCID 97587 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 5-(4-Trifluoromethylphenyl)-6-phenylpyridine-2-carbaldehyde | HCID 86619071 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (3-{[6-Phenyl-5-(4-trifluoromethylphenyl)-pyridin-2-ylmethyl]-amino}-propyl)-phosphonic Acid | HCID 59504176 | — |
反応手順
Following General Procedure M, 5-(4-trifluoromethylphenyl)-6-phenyl-pyridine-2-carbaldehyde (Compound 57, 58 mg, 0.18 mmol), (3-amino-propyl)-phosphonic acid (25 mg, 0.18 mmol), Bu4NOH (0.18 ml, 0.18 mmol, 1 M in MeOH) and NaCNBH3 (11 mg, 0.18 mmol) in MeOH (3 ml) were reacted to produce the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728014B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6c223868fa6e418e812f48b461d0ad88 |
| 出典メモ | uspto-grants-2010_06 |