Phosphorus tribromide → 3-Fluoro-4-(methylsulphonyl)benzyl bromide

HRID 1254900ノート

反応式

HRID 1254900 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:12]O)[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].P(Br)(Br)[Br:15]>C(OCC)C.O>[Br:15][CH2:12][C:4]1[CH:5]=[CH:6][C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[C:2]([F:1])[CH:3]=1

参加物

5

反応物 2

HCID 24614Phosphorus tribromideHCID 672190853-Fluoro-4-(methylsulphonyl)benzyl alcohol

生成物 1

HCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a stirred suspension of (3-fluoro-4-methanesulfonyl-phenyl)-methanol (0.269 g, 1.31 mmol) in diethyl ether (5 ml) under an inert atmosphere of Argon is added dropwise phosphorus tribromide (46 μl, 0.434 mmol). After stirring at room temperature overnight, the reaction mixture is diluted with water (2 ml) and the diethyl ether layer separated. This organic portion is placed over NaOH pellets and after 20 minutes, is used as a reagent in solution in diethyl ether.

後処理

  1. customthe diethyl ether layer separated
  2. waitThis organic portion is placed over NaOH pellets and after 20 minutes

出典と根拠

ORDレコード
ord-ef5ace8d54f3449a913d26916b6f86c6
出典データセット
uspto-grants-2013_06
特許番号
US08455645B2

反応ノート

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