化工社化工社 化学情報印刷レポート · 研究参考用
3-Aminopropylphosphonic acid → 3-((6-Phenyl-5-(4-propylphenyl)pyridin-2-yl)methylamino)propylphosphonic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Aminopropylphosphonic acid | HCID 97587 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 6-Phenyl-5-(4-propylphenyl)pyridine-2-carbaldehyde | HCID 86619075 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-((6-Phenyl-5-(4-propylphenyl)pyridin-2-yl)methylamino)propylphosphonic Acid | HCID 49787250 | — |
反応手順
Following General Procedure M, 6-phenyl-5-(4-propylphenyl)pyridine-2-carbaldehyde (Compound 59, 74 mg, 0.25 mmol), (3-amino-propyl)phosphonic acid (34 mg, 0.25 mmol), Bu4NOH (0.25 ml, 0.25 mmol, 1M in MeOH) and NaCNBH3 (15 mg, 0.25 mmol) in MeOH (5 ml) were reacted to produce the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728014B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-7379c5469345430caa35630f18548b1c |
| 出典メモ | uspto-grants-2010_06 |