2-(2,6-Difluorobenzamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid → 2-(3-Methylisonicotinamido)-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid
反応式
Cl.[CH3:2][C:3]1[CH:30]=[N:29][CH:28]=[CH:27][C:4]=1[C:5]([NH:7][C:8]1[S:9][C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)=[C:11]([C:13]([O:15]C)=[O:14])[N:12]=1)=[O:6].FC1C=CC=C(F)C=1C(NC1SC(C2C=CC=C(C(F)(F)F)C=2)=C(C(O)=O)N=1)=O>>[CH3:2][C:3]1[CH:30]=[N:29][CH:28]=[CH:27][C:4]=1[C:5]([NH:7][C:8]1[S:9][C:10]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1)=[O:6]参加物
3
反応物 2
生成物 1
実験手順
Compound 112 was prepared from Compound 111 by hydrolysis similarly as described for the preparation of Compound 66.
出典と根拠
- ORDレコード
- ord-834d54e4c8724dc18723c03aa88c1860
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08455658B2
反応ノート
読み込み中…