Hydrochloric Acid → HCID 67446199、化合物
反応式
[ClH:1].[F:2][C:3]1([F:16])[CH2:7][CH2:6][C@@H:5]([NH:8]C(=O)OC(C)(C)C)[CH2:4]1>O1CCOCC1>[ClH:1].[F:2][C:3]1([F:16])[CH2:7][CH2:6][C@@H:5]([NH2:8])[CH2:4]1参加物
4
実験手順
Hydrochloric acid (4M in dioxane, 60 mL) was added to a solution of (R)-tert-butyl 3,3-difluorocyclopentylcarbamate (4.61 g, 20.8 mmol) in dioxane (40 mL) at 0° C. After complete addition, the reaction mixture was allowed to warm to room temperature and stirred for 2 hours. The solvent was removed in vacuo and the residue was triturated with diethylether to afford the title compound as an off-white solid (2.68 g, 82% yield).
後処理
- additionAfter complete addition
- customThe solvent was removed in vacuo
- customthe residue was triturated with diethylether
出典と根拠
- ORDレコード
- ord-f471a62e11134988ab242a1997f0de4c
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461149B2
反応ノート
読み込み中…