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Toluene → 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate | HCID 68408073 | — |
| 生成物 | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-ethanone | HCID 59338806 | — |
反応手順
Following General Procedure O, 6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester (Compound 25, 49 mg, 0.13 mmol) in toluene (3 ml), N,N′-dimethylethylenediamine (DMEDA, 13 mg, 0.15 mmol) and trimethylaluminum (0.2 ml, 2.64 mmol, 2 M in toluene) were reacted to produce the title compound as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728014B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f6180a6a9d6c4c78af7473d6405c1164 |
| 出典メモ | uspto-grants-2010_06 |