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N,N'-Dimethylethylenediamine → 1-[5-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 反応物 | Triethylaluminum | HCID 16682930 | — |
| 反応物 | Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate | HCID 68407826 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-[5-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one | HCID 25033168 | — |
反応手順
Following General Procedure O, 5-phenyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester (Compound 29, 292 mg, 0.71 mmol) in toluene (5 ml), N,N′-dimethylethylenediamine (DMEDA, 76 mg, 0.86 mmol) and triethylaluminum (2.4 ml, 0.35 mmol, 1 M in hexane) were reacted to produce the title compound as a oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728014B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-fec3f79e1b134d3c9cf24eaca51232e1 |
| 出典メモ | uspto-grants-2010_06 |