化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1-[3-(4-Chloro-phenoxy)-benzyl]-piperazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 4-[3-(4-Chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 67413541 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 1-[3-(4-Chloro-phenoxy)-benzyl]-piperazine hydrochloride | HCID 67413809 | 211.7% |
反応手順
A solution of 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester (29.6 g, 73.5 mmol) in 4:1 dioxane:H2O (100 mL) was treated with 4 M HCl in dioxane (60 mL). After 3 h, THF (200 mL) was added and the resulting white precipitate was filtered and dried under vacuum to give 1-[3-(4-chloro-phenoxy)-benzyl]-piperazine hydrochloride (26.4 g, 95%). MS (ESI+): calcd for C17H19ClN2O m/z 302.12. found 303.1 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08461159B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-28773168541343ac8ec05a9822fa13b3 |
| 出典メモ | uspto-grants-2013_06 |