化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Methyl (2E)-3-(3-nitrophenyl)-2-propenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 反応物 | Trimethyl phosphonoacetate | HCID 80029 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl (2E)-3-(3-nitrophenyl)-2-propenoate | HCID 5354136 | 98% |
反応手順
To a solution of 3-nitro-benzaldehyde (15 g, 0.1 mol), (dimethoxy-phosphoryl)-acetic acid methyl ester (27 g, 0.148 mol) in DMF (100 ml) was added NaOMe (10.7 g 0.198 mol). The reaction was monitored by TLC. After reaction was completed, the reaction mixture was adjusted to pH=1 with aqueous HCl solution and evaporated. The resulting solid was washed with water to afford (E)-methyl 3-(3-nitrophenyl)acrylate as a yellow solid (20.14 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08461157B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-faa260799f1e4e92b1806c51c06131dd |
| 出典メモ | uspto-grants-2013_06 |