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Hydrochloric Acid → methyl (E)-3-(3-aminophenyl)acrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl (2E)-3-(3-nitrophenyl)-2-propenoate | HCID 5354136 | — |
| 触媒 | Iron | HCID 23925 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | methyl (E)-3-(3-aminophenyl)acrylate | HCID 12394366 | 57% |
反応手順
A solution of (E)-methyl 3-(3-nitrophenyl)acrylate (20.14 g, 0.097 mol), Fe (32.5 g, 0.58 mol), concentrated HCl (3.5 ml) in 50% EtOH (100 ml) was refluxed for 2 h. Upon completion, the solution was filtered through Celite and washed with EtOH. The filtrate was concentrated and extracted with dichloromethane. The combined organic phase was dried over MgSO4 and concentrated to afford (E)-methyl 3-(3-aminophenyl)acrylate as a yellow solid (9.73 g, 57%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08461157B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-23aa94ce1d194a229de0a8a67b963dde |
| 出典メモ | uspto-grants-2013_06 |