Ethanol → 6-Bromopyrazolo[1,5-a]pyrimidine

HRID 1255861ノート

反応式

HRID 1255861 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[Br:7]/[C:8](=[CH:11]\N(C)C)/[CH:9]=O.C(O)C>C(O)(=O)C>[Br:7][C:8]1[CH:9]=[N:1][C:2]2[N:3]([N:4]=[CH:5][CH:6]=2)[CH:11]=1

参加物

5

反応物 3

HCID 702EthanolHCID 215914792-Bromo-3-(dimethylamino)acroleinHCID 178418806HCID 178418806、化合物

生成物 1

HCID 222367016-Bromopyrazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3-Aminopyrazole (0.75 g, 9.04 mmol) was mixed with (2Z)-2-bromo-3-(dimethylamino)acrylaldehyde obtained at the previous step (1.85 g, 10.4 mmol). Absolute ethanol (20 mL) and glacial acetic acid (2 mL) were added. The reaction mixture was stirred under reflux for 16 h and evaporated to dryness. The residue was washed on a filter with cold ethanol/hexane mixture (3:1) and dried in a vacuum oven at 30° C. to give 6-bromopyrazolo[1,5-a]pyrimidine.

後処理

  1. customobtained at the previous step (1.85 g, 10.4 mmol)
  2. temperatureunder reflux for 16 h
  3. customevaporated to dryness
  4. washThe residue was washed on
  5. filtrationa filter with cold ethanol/hexane mixture (3:1)
  6. customdried in a vacuum oven at 30° C.

出典と根拠

ORDレコード
ord-8193ef84867742bfaacde2bfec964037
出典データセット
uspto-grants-2013_06
特許番号
US08461162B2

反応ノート

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