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Potassium → 2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium | HCID 5462222 | — |
| 反応物 | 4-[(3,4-Dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline | HCID 11176185 | — |
| 反応物 | 2,2,3,3-Tetramethyl-4,7,10,13,16,19-hexaoxa-3-silahenicosan-21-ol | HCID 11825440 | — |
| 反応物 | 2-{2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy}-ethanol | HCID 69266955 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanol | HCID 69261526 | 56% |
反応手順
Compound 29c was prepared as described hereinabove for Compound 29a, using Compound 25 (0.596 gram, 1.6 mmol), 2-[2-(2-{2-[2-(2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy}-ethoxy]-ethanol (Compound 28c, 0.957 gram, 2.4 mmol), and potassium trimethylsilonate (0.621 gram, 4.74 mmol) dissolved in DMSO (37 ml). The crude residue was purified by silica gel column chromatography, using a mixture of 2% methanol in dichloromethane as eluent, to obtain Compound 29c (0.568 gram, 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08461166B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-aa13f2da1f004efd90839764b8bbc928 |
| 出典メモ | uspto-grants-2013_06 |