2-[2-(2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy)-ethoxy}-ethoxy]-ethoxy)-ethanol → N4-(4,5-Dichloro-2-fluoro-phenyl)-7-{2-[2-(2-{2-[2-ethoxy-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-quinazoline-4,6-diamine
反応式
ClC1C(Cl)=CC(NC2C3C(=CC(OCCOCC)=C(N)C=3)N=CN=2)=C(F)C=1.[Cl:28][C:29]1[C:34]([Cl:35])=[CH:33][C:32]([NH:36][C:37]2[C:46]3[C:41](=[CH:42][C:43]([O:50][CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][O:65][CH2:66][CH2:67]O)=[C:44]([N+:47]([O-])=O)[CH:45]=3)[N:40]=[CH:39][N:38]=2)=[C:31]([F:69])[CH:30]=1>>[Cl:28][C:29]1[C:34]([Cl:35])=[CH:33][C:32]([NH:36][C:37]2[C:46]3[C:41](=[CH:42][C:43]([O:50][CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59][CH2:60][CH2:61][O:62][CH2:63][CH2:64][O:65][CH2:66][CH3:67])=[C:44]([NH2:47])[CH:45]=3)[N:40]=[CH:39][N:38]=2)=[C:31]([F:69])[CH:30]=1参加物
3
反応物 2
生成物 1
実験手順
Compound 41c was prepared as described hereinabove for Compound 41a, using Compound 29c as a starting material.