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Pyridine → 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one O-Methyloxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| 反応物 | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one | HCID 59338833 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one O-Methyloxime | HCID 72258470 | — |
反応手順
Following General Procedure P, 1-[6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one (Compound 78), (24 mg, 0.07 mmol), NH2OMe—HCl (23 mg, 0.25 mmol) and pyridine (21 mg, 0.28 mmol) in EtOH (2 ml) were reacted to give title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728014B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-28bcb12bc8624d6c93962d8249bed849 |
| 出典メモ | uspto-grants-2010_06 |