Tolylboronic acid → 7-(4-Methylphenyl)pyrazolo[1,5-a]pyrimidin-5-amine

反応式

Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([NH2:11])[CH:3]=1.B(O)(O)[C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=1>>[C:16]1([CH3:19])[CH:17]=[CH:18][C:13]([C:2]2[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=[C:4]([NH2:11])[CH:3]=2)=[CH:14][CH:15]=1

参加物

反応物 2

HCID 79799Tolylboronic acid

HCID 442513067-Chloropyrazolo[1,5-a]pyrimidin-5-amine

生成物 1

HCID 582073627-(4-Methylphenyl)pyrazolo[1,5-a]pyrimidin-5-amine

実験手順

The titled compound was prepared using a procedure analogous to that described in connection with Example 15 except that 7-chloropyrazolo[1,5-a]pyrimidin-5-amine (1E) and p-tolylboronic acid were used as starting materials. 1H NMR (400 MHz, CHLOROFORM-d) δ 2.44 (s, 3H), 4.82 (s, 2H), 6.16 (s, 1H), 6.20 (d, J=2.0 Hz, 1H), 7.34 (d, J=8.1 Hz, 2H), 7.81 (d, J=8.1 Hz, 2H), 7.91 (d, J=2.0 Hz, 1H).

出典と根拠

ORDレコード: ord-73d11acd8b604f26ad79f7b8ea805ed2
出典データセット: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08461163B2

反応ノート

読み込み中…