Tert-Butylamine → N-tert-butyl-2-nitro-4-(trifluoromethyl)aniline

HRID 1256622ノート

反応式

HRID 1256622 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CN1CCCC1=O.[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>O>[C:22]([NH:26][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])([CH3:25])([CH3:24])[CH3:23]

参加物

5

反応物 3

HCID 6385Tert-ButylamineHCID 13387N-methyl-2-pyrrolidoneHCID 677784-Fluoro-3-nitrobenzotrifluoride

生成物 1

HCID 2736447N-tert-butyl-2-nitro-4-(trifluoromethyl)aniline収率 81.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 5.22 g of 4-fluoro-3-nitro-benzo trifluoride and 25 ml of N-methylpyrrolidone was added 3.88 g of tert-butylamine, and the mixture was stirred for 2 hours at room temperature. The reaction mixture was poured into water, the deposited solid was collected by filtration. This solid was washed with water, then, dried under reduced pressure, to obtain 5.35 g of N-tert-butyl-2-nitro-4-trifluoromethylaniline.

後処理

  1. filtrationthe deposited solid was collected by filtration
  2. washThis solid was washed with water
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-5b34e1fa7dc04e48989dd2b8aea57fee
出典データセット
uspto-grants-2013_06
特許番号
US08461181B2

反応ノート

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