Metformin Hydrochloride → 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)

HRID 1256935ノート

反応式

HRID 1256935 の反応式
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10].[CH3:11][CH:12]1OC(C)OC(C)O1>C(O)C(C)C.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[ClH:10].[NH2:8][C:7]1[NH:6][C:4]([N:2]([CH3:3])[CH3:1])=[N:5][CH:11]([CH3:12])[N:9]=1

参加物

5

反応物 2

HCID 14219Metformin HydrochlorideHCID 31264Paraldehyde

生成物 1

HCID 101764861,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)収率 183.1%

試薬・触媒・溶媒 2

HCID 521998p-Toluenesulfonic acid monohydrate触媒HCID 6560Isobutanol溶媒

実験手順

A mixture of 1002.6 g of metformin hydrochloride, 359.1 g of paraldehyde and 51.6 g of toluene-4-sulfonic acid monohydrate in 2405.9 g of isobutanol is heated under reflux for 6 hours. Some of the solvent is removed by distillation. The mixture is cooled to 12°, and the white precipitate is separated off, giving 953.8 g (81.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 6 hours
  3. customSome of the solvent is removed by distillation
  4. temperatureThe mixture is cooled to 12°
  5. customthe white precipitate is separated off

出典と根拠

ORDレコード
ord-76c475bd77424e0dbfe513292e2657e1
出典データセット
uspto-grants-2013_06
特許番号
US08461331B2

反応ノート

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