Acetyl chloride → Tert-butyl 4-acetylpiperazine-1-carboxylate
反応式
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(N(CC)CC)C.[C:21](Cl)(=[O:23])[CH3:22]>ClCCl>[C:21]([N:11]1[CH2:10][CH2:9][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:13][CH2:12]1)(=[O:23])[CH3:22]参加物
5
実験手順
A solution of N-Boc-piperazine (300 mg, 1.63 mmol), triethylamine (494 mg, 3 equiv), and acetyl chloride (1.5 equiv) in dichloromethane was stirred overnight at rt. The solution was quenched by the dropwise addition of water. The organic layer was separated, dried over anhydrous Na2SO4, and evaporated in vacuo. The residue was purified by flash chromatography to give the title compound (˜85% yield) as a solid.
後処理
- customThe solution was quenched by the dropwise addition of water
- customThe organic layer was separated
- dry with materialdried over anhydrous Na2SO4
- customevaporated in vacuo
- customThe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-17373938cac64b8cac4b38ed704fe09c
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461339B2
反応ノート
読み込み中…