Potassium Carbonate → 1-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine

HRID 1257110

反応式

HRID 1257110 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:10][C:11]1[CH:16]=[C:15]([CH2:17]Cl)[CH:14]=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:10][C:11]1[CH:16]=[C:15]([CH2:17][N:7]2[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]2)[CH:14]=[CH:13][N:12]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 111265732-Chloro-4-(chloromethyl)pyridine

生成物 1

HCID 582851821-(2-Chloropyridin-4-ylmethyl)-4-acetylpiperazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-Acetylpiperazine (1.0 equiv) was mixed with compound 2-chloro-4-(chloro-methyl)pyridine (1.0 equiv) and K2CO3 (4 equiv) in DMF. The mixture was stirred for 1 h at rt. After removing most of the solvent, the residue was partitioned in water and EtOAc. The organic layer was separated, dried over anhydrous Na2SO4, and evaporated in vacuo. The residue was purified by flash chromatography to give the title compound as a solid.

後処理

  1. customAfter removing most of the solvent
  2. customthe residue was partitioned in water
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous Na2SO4
  5. customevaporated in vacuo
  6. customThe residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-99434ad2b24e4ade9640c921364c5de3
出典データセット
uspto-grants-2013_06
特許番号
US08461339B2

関連ノート

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