Hydrogen chloride-ethyl acetate → Isoquinolin-3-yl-(4-piperazin-1-ylmethyl-pyridin-2-yl)-amine

HRID 1257125

反応式

HRID 1257125 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([NH:11][C:12]2[CH:17]=[C:16]([CH2:18][N:19]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[CH:15]=[CH:14][N:13]=2)[N:2]=1.Cl.CCOC(C)=O>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([NH:11][C:12]2[CH:17]=[C:16]([CH2:18][N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[CH:15]=[CH:14][N:13]=2)[N:2]=1

参加物

3

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 671756022-(Isoquinolin-3-ylamino)-4-(4-tert-butoxycarbonylpiperazin-1-ylmethyl)-pyridine

生成物 1

HCID 44612469Isoquinolin-3-yl-(4-piperazin-1-ylmethyl-pyridin-2-yl)-amine

実験手順

2-(Isoquinolin-3-ylamino)-4-(4-tert-butoxycarbonylpiperazin-1-ylmethyl)-pyridine was treated with 8 M HCl/EtOAc to afford the title compound as a salt in near quantitative yield (50 mg). 1H NMR (CDCl3, 300 MHz) δ: 3.44 (s, 4H, PyridylCH2NCH2CH2), 3.45 (s, 4H, NHCH2), 4.25 (s, 2H, pyridylCH2), 7.01-8.87 (m, 9H, isoquinolyl+pyridyl).

出典と根拠

ORDレコード
ord-6e1513559b534a36b9eed6453a776314
出典データセット
uspto-grants-2013_06
特許番号
US08461339B2

関連ノート

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