3-(Trifluoromethyl)benzaldehyde → (2E)-3-(3-(trifluoromethyl)phenyl)prop-2-enal
反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=O.C1(P(=[CH:32][CH:33]=[O:34])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5](/[CH:6]=[CH:32]/[CH:33]=[O:34])[CH:8]=[CH:9][CH:10]=1参加物
4
実験手順
3-(Trifluoromethyl)benzaldehyde (0.70 g) was dissolved in toluene (16 mL), and (triphenylphosphoranylidene)acetoaldehyde (1.22 g) was added. The reaction mixture was heated under reflux for 40 hr and concentrated, and the residue was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate) to give the title compound (0.41 g) as an oil.
後処理
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 40 hr
- concentrationconcentrated
- customthe residue was purified by column chromatography (carrier: silica gel, eluent: hexane-ethyl acetate)
出典と根拠
- ORDレコード
- ord-cd80c6a0bba347869be0533b44a11e18
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08461348B2
反応ノート
読み込み中…