化工社化工社 化学情報印刷レポート · 研究参考用
Cesium carbonate → Methyl 5-methyl-4-[3-(trifluoromethyl)phenyl]furan-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Methyl 4-bromo-5-methylfuran-2-carboxylate | HCID 604544 | — |
| 反応物 | 3-(Trifluoromethyl)phenylboronic acid | HCID 2734388 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 生成物 | Methyl 5-methyl-4-[3-(trifluoromethyl)phenyl]furan-2-carboxylate | HCID 66939668 | 61.6% |
反応手順
By a method similar to that in Example 126c and using the compound (1.00 g) obtained in Example 128b, 3-(trifluoromethyl)phenylboronic acid (1.04 g), cesium carbonate (2.98 g, 3.6 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.19 g), the title compound (0.80 g) was obtained as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08461348B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-1f74dbfc745b413db299c206ace20811 |
| 出典メモ | uspto-grants-2013_06 |