Water → 5-(3-(Trifluoromethyl)phenyl)furfural

HRID 1257477

反応式

HRID 1257477 の反応式
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([CH2:14][OH:15])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.O>ClCCl>[F:16][C:2]([F:1])([F:17])[C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12]([CH:14]=[O:15])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 962WaterHCID 159087TriacetoxyperiodinaneHCID 7782745{5-[3-(trifluoromethyl)phenyl]furan-2-yl}methanol

生成物 1

HCID 7218375-(3-(Trifluoromethyl)phenyl)furfural

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the compound (0.45 g) obtained in Example 130b in dichloromethane (4 mL) was cooled in an ice bath, and Dess-martin reagent (0.94 g) was added. After stirring at room temperature for 1 hr, water was added to the reaction mixture, and the mixture was extracted with dichloromethane. The organic layer was washed with saturated aqueous sodium thiosulfate solution, dried over magnesium sulfate, and concentrated under reduced pressure to give a crude title compound.

後処理

  1. extractionthe mixture was extracted with dichloromethane
  2. washThe organic layer was washed with saturated aqueous sodium thiosulfate solution
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c14da28565a44c74a7cdb7c0a1816852
出典データセット
uspto-grants-2013_06
特許番号
US08461348B2

関連ノート

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