6-Amino-3-propylpyrimidine-2,4(1H,3H)-dione → 6-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1258025ノート

反応式

HRID 1258025 の反応式
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[CH:3]=1.[N:13]([O-])=[O:14].[Na+]>C(O)(=O)C.O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[N:13]=[O:14]

参加物

4

反応物 2

HCID 110302506-Amino-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 23668193Sodium Nitrite

生成物 1

HCID 144253236-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

試薬・触媒・溶媒 1

HCID 21899381Acetic acid--water (1/1)溶媒

反応条件

温度
70 °C

実験手順

To a solution of 6-amino-3-propyl-1,3-dihydropyrimidine-2,4-dione (5.6 g) in a mixture of 50% acetic acid/water (160 ml) at 70° C. was added sodium nitrite (4.5 g) in portions over a period of 15 minutes. The mixture was stirred at 70° C. for 45 minutes, then the reaction mixture concentrated to a low volume under reduced pressure. The solid was filtered off, and washed with water, to provide 6-amino-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (11).

後処理

  1. concentrationthe reaction mixture concentrated to a low volume under reduced pressure
  2. filtrationThe solid was filtered off
  3. washwashed with water

出典と根拠

ORDレコード
ord-b0334e5408d3410ba9dceaf80f8f5249
出典データセット
uspto-grants-2013_06
特許番号
US08466129B2

反応ノート

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