Hydrochloric Acid → HCID 42281543、化合物

HRID 1258118

反応式

HRID 1258118 の反応式
[C:1]1(=[O:13])[O:10][C:8](=[O:9])[CH:7]2[CH2:11][CH2:12][C:2]1([C:4]2([CH3:6])[CH3:5])[CH3:3].Cl.[CH3:15][NH2:16]>CN(C1C=CN=CC=1)C>[CH3:3][C@@:2]1([C:1]([OH:10])=[O:13])[CH2:12][CH2:11][C@H:7]([C:8](=[O:9])[NH:16][CH3:15])[C:4]1([CH3:6])[CH3:5]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 948341,8,8-Trimethyl-3-oxabicyclo[3.2.1]octane-2,4-dione

生成物 1

HCID 42281543HCID 42281543、化合物

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

実験手順

A mixture of 40% aqueous methylamine (70 mL) and camphoric anhydride (5 g) was stirred at room temperature for 30 minutes. To this N,N-dimethyl-4-aminopyridine (DMAP) (0.67 g, 5.4 mmol) was added and stirred further for 24 hours. The reaction mixture was allowed to cool to room temperature and acidified with con. HCl at 0-5° C. White precipitate formed was filtered and dried (5.2 g). m/z (M+H): 214.1.

後処理

  1. stirringstirred further for 24 hours
  2. temperatureto cool to room temperature
  3. customat 0-5° C
  4. customWhite precipitate
  5. customformed
  6. filtrationwas filtered
  7. customdried (5.2 g)

出典と根拠

ORDレコード
ord-1be69acfa2d24dae8fcb58eb7f2d0830
出典データセット
uspto-grants-2013_06
特許番号
US08466145B2

関連ノート

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