[3-(Benzyloxy)-4-methylphenyl]methanol → 3-(Benzyloxy)-4-methylbenzaldehyde
反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:16][OH:17])[CH:12]=[CH:13][C:14]=1[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH:16]=[O:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of (3-benzyloxy-4-methylphenyl)methanol (1.0 g) in dichloromethane (50 mL) was added manganese dioxide (2.5 g), and this mixture was stirred at room temperature for 2 days. The insoluble material was removed by filtration and this filtrate was concentrated under reduced pressure. This residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate) to give the title compound (0.39 g)
後処理
- customThe insoluble material was removed by filtration
- concentrationthis filtrate was concentrated under reduced pressure
- customThis residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate)
出典と根拠
- ORDレコード
- ord-02da5e67bfd0469ebdcb1cd1b898d625
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466152B2
反応ノート
読み込み中…