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HRID 1258211作成日：2026年10月27日
Water → 4-[6-(2-Benzyloxycarbonylaminoethyloxy)-3-cyanoindol-1-yl]-2-methoxymethoxy-benzoic acid ethyl ester
https://huagongshe.com/reaction/1258211
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | benzyl N-(2-bromoethyl)carbamate | HCID 278694 | — |
| 反応物 | 4-(3-Cyano-6-hydroxyindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester | HCID 58437526 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[6-(2-Benzyloxycarbonylaminoethyloxy)-3-cyanoindol-1-yl]-2-methoxymethoxy-benzoic acid ethyl ester | HCID 58437239 | 72.9% |
反応手順
To a solution of 4-(3-cyano-6-hydroxyindol-1-yl)-2-methoxymethoxybenzoic acid ethyl ester (0.37 g) in N,N-dimethylformamide (10 mL) were added (2-bromoethyl)carbamic acid benzyl ester (0.39 g) and potassium carbonate (0.28 g), and this mixture was stirred at 50° C. overnight. This reaction mixture was poured into water, and the precipitated solid was collected by filtration. This solid was washed with methanol, and dried to give the title compound (0.40 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08466152B2 |
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| 出典データセット | uspto-grants-2013_06 |
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| ORD ID | ord-5f6ed8e64ad847c2ae2533b7e92a129c |
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| 出典メモ | uspto-grants-2013_06 |
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