Iodine → N-(3-iodo-4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide

反応式

Br[C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[C:5]2[C:10]([C:11]=1[OH:12])=[CH:9][CH:8]=[CH:7][CH:6]=2.[I:22]I>>[I:22][C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[C:5]2[C:10]([C:11]=1[OH:12])=[CH:9][CH:8]=[CH:7][CH:6]=2

参加物

反応物 2

HCID 807Iodine

HCID 7718544N-(3-bromo-4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide

生成物 1

HCID 46909346N-(3-iodo-4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide収率 100%

実験手順

was prepared according to the procedure for 4b except using I2 solid. The reaction afforded title compound 129.4 mg (100%) as a brown solid, m.p.: 134-136° C.

後処理

customwas prepared

出典と根拠

ORDレコード: ord-3cc4bb9da5e3467d9f9aac187c045266
出典データセット: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08466157B2

反応ノート

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