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Trifluoroacetic acid → (R)-2-Amino-4-(4-heptyloxy-phenyl)-2-methyl-butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | (R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid | HCID 58897679 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (R)-2-Amino-4-(4-heptyloxy-phenyl)-2-methyl-butanoic acid | HCID 11404040 | — |
反応手順
To a stirred solution of (R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid (43 mg, 0.11 mMol) in CH2Cl2 (2 ml) is added trifluoroacetic acid (0.1 ml). The mixture is stirred at RT for 8 hours. After that time, the reaction mixture is concentrated under reduced pressure. Column chromatography eluting with 5%→25% MeOH in CH2Cl2 gives the title compound as a colourless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728020B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-dc96f4ef043c40f5b91e8bb96a45a857 |
| 出典メモ | uspto-grants-2010_06 |