1,1'-Thiocarbonyldi-2(1H)-pyridone → HCID 86646343、化合物

HRID 1258634ノート

反応式

HRID 1258634 の反応式
[C:1](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:2].[NH2:17][C:18]1[CH:19]=[C:20]([CH:29]=[CH:30][C:31]=1[Cl:32])[CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25]>C(Cl)Cl>[Cl:32][C:31]1[CH:30]=[CH:29][C:20]([CH2:21][NH:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])=[CH:19][C:18]=1[N:17]=[C:1]=[S:2]

参加物

4

反応物 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 66765386N-(3-amino-4-chlorobenzyl)pivalamide

生成物 1

HCID 86646343HCID 86646343、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1,1′-Thiocarbonyldi-2-pyridone (2.12 g, 9.1 mmol) was added to a mixture of N-(3-amino-4-chlorobenzyl)-2,2-dimethyl-propionamide (2.00 g, 8.3 mmol) and DCM (60 mL) and stirred at rt for 1.5 h. The mixture was filtered over silica gel. The organic layer was concentrated to give the sub-title compound.

後処理

  1. filtrationThe mixture was filtered over silica gel
  2. concentrationThe organic layer was concentrated

出典と根拠

ORDレコード
ord-7125d667e7ff480ebce03b54f597e544
出典データセット
uspto-grants-2013_06
特許番号
US08466186B2

反応ノート

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