Acetic Acid → 3-Amino-2,4-dichlorobenzoic acid

HRID 1258646ノート

反応式

HRID 1258646 の反応式
C([NH:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=O)C.C(O)(=O)C>Cl>[NH2:4][C:5]1[C:6]([Cl:15])=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 198331103-Acetamido-2,4-dichlorobenzoic acid

生成物 1

HCID 152782343-Amino-2,4-dichlorobenzoic acid

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

3-Acetylamino-2,4-dichloro-benzoic acid (21.0 g, 84.6 mmol) was stirred in 6 M aq. HCl-solution (120 mL) and acetic acid (250 mL) at reflux for 24 h. The reaction mixture was cooled, concentrated, diluted with water and concentrated again. The residue was diluted with water, stirred under cooling and filtered. The filtercake was washed and dried to give the sub-title compound.

後処理

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. additiondiluted with water
  4. concentrationconcentrated again
  5. additionThe residue was diluted with water
  6. temperatureunder cooling
  7. filtrationfiltered
  8. washThe filtercake was washed
  9. customdried

出典と根拠

ORDレコード
ord-b48597ec34394e1e8283ebe92fde53a7
出典データセット
uspto-grants-2013_06
特許番号
US08466186B2

反応ノート

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