Acetyl chloride → N-(5,6-dichloropyridin-3-yl)acetamide

HRID 1259138ノート

反応式

HRID 1259138 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[CH:5]=[N:6][C:7]=1[Cl:8].C(N(CC)CC)C.[C:17](Cl)(=[O:19])[CH3:18]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:17](=[O:19])[CH3:18])[CH:5]=[N:6][C:7]=1[Cl:8]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 145952195-Amino-2,3-dichloropyridine

生成物 1

HCID 86652352N-(5,6-dichloropyridin-3-yl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 5,6-dichloropyridin-3-amine (commercially available) and triethyl amine (3 eq) in CH2Cl2 (0.2 M) at 0° C. was added acetyl chloride (2 eq). After stirring at room temperature overnight the reaction mixture was concentrated under vacuum and the resulting crude residue was purified by chromatography (silica gel, 20-50% EtOAc in hexanes) to afford N-(5,6-dichloropyridin-3-yl)acetamide.

後処理

  1. concentrationwas concentrated under vacuum
  2. customthe resulting crude residue was purified by chromatography (silica gel, 20-50% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-86fe29c5dd154d17ae1e7c5347ad4677
出典データセット
uspto-grants-2013_06
特許番号
US08466167B2

反応ノート

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