Imidazole → (R)-tert-Butyldimethyl(oxiran-2-ylmethoxy)silane
反応式
[CH2:1]1[O:3][C@H:2]1[CH2:4][OH:5].[CH3:6][C:7]([Si:10](Cl)([CH3:12])[CH3:11])([CH3:9])[CH3:8].N1C=CN=C1>C(Cl)Cl.CN(C=O)C.C(Cl)Cl>[C:7]([Si:10]([CH3:12])([CH3:11])[O:5][CH2:4][C@H:2]1[CH2:1][O:3]1)([CH3:9])([CH3:8])[CH3:6]参加物
6
反応条件
- 温度
- 0 °C
実験手順
A solution of (S)-glycidol (2.5 g, 33.7 mmol) in 100 mL of 1:1 DCM/DMF was cooled to 0° C. and treated with TBDMS-Cl (6.10 g, 40.5 mmol) and imidazole (3.45 g, 50.6 mmol). The mixture was stirred overnight at 0° C. Solution was diluted with DCM and washed with saturated aqueous NaHCO3 and brine, dried over Na2SO4 and concentrated to provide A-1 as a colorless oil. Data for A-1: LRMS m/z (M+H)=189.21 found; 189.34 required
後処理
- washwashed with saturated aqueous NaHCO3 and brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
- customto provide A-1 as a colorless oil
出典と根拠
- ORDレコード
- ord-1f7387fc9ad44240a768827be4248542
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08466281B2
反応ノート
読み込み中…