tert-Butyl carbazate → 5-Methyl-2-furohydrazide

Tert-butyl carbazate (549 mg, 4.15 mmol) was added to a methylene chloride (10 mL) solution of commercially available 5-methylfuran-2-carbonyl chloride (500 mg, 3.46 mmol) under ice cooling, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, and then, the residue was dissolved in methylene chloride (10 mL). To the solution, trifluoroacetic acid (2 mL) was added, and the mixture was stirred at room temperature for 1.5 hours. The reaction solution was concentrated to obtain 5-methylfuran-2-carbohydrazide.

1. concentrationThe reaction solution was concentrated
2. dissolutionthe residue was dissolved in methylene chloride (10 mL)
3. additionTo the solution, trifluoroacetic acid (2 mL) was added
4. stirringthe mixture was stirred at room temperature for 1.5 hours
5. concentrationThe reaction solution was concentrated

ORDレコード

ord-694b64273cac4806be76eab314deb09a

出典データセット

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08466290B2