Hydrazine → tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

HRID 1260286ノート

反応式

HRID 1260286 の反応式
C[C:2]1([C:14]([O-:16])=O)[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[NH2:17][NH2:18]>C(O)C>[NH:17]([C:14]([CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1)=[O:16])[NH2:18]

参加物

4

反応物 2

HCID 9321HydrazineHCID 713021051-Tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate

生成物 1

HCID 4621605tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 1-tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate (1.00 equiv.) and hydrazine (excess of 50% aq. solution) in ethanol (0.2 M final conc.) is heated to reflux. After the reaction is deemed complete, the reaction mixture is cooled to rt and partially concentrated. The resulting mixture is diluted with EtOAc, and the resulting organics are washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound i-12a.

後処理

  1. concentrationpartially concentrated
  2. additionThe resulting mixture is diluted with EtOAc
  3. washthe resulting organics are washed with water and brine
  4. dry with materialdried (sodium sulfate)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-475c15a422bb48de9c3a67e81c75ad45
出典データセット
uspto-grants-2013_06
特許番号
US08470819B2

反応ノート

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