Ethyl 3-amino-6-bromopicolinate → Ethyl 3-amino-6-cyanopyridine-2-carboxylate

HRID 1260308ノート

反応式

HRID 1260308 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8](Br)[N:7]=1)=[O:5])[CH3:2].[Cu][C:15]#[N:16]>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]([C:15]#[N:16])[N:7]=1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 25137688Ethyl 3-amino-6-bromopicolinateHCID 178418546HCID 178418546、化合物

生成物 1

HCID 58368044Ethyl 3-amino-6-cyanopyridine-2-carboxylate収率 26.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 3-amino-6-bromo-pyridine-2-carboxylic acid ethyl ester (40 mg, 163 μmol) and copper(I) cyanide (29.2 mg, 326 μmol) in DMF (800 μL) was heated in the microwave at 220° C. for 8 min. The reaction mixture was filtered through diatomaceous filter-aid and the crude product was purified by preparative HPLC to afford the title compound as off-white solid (8.3 mg, 26.6%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. filtrationthrough diatomaceous filter-aid
  3. customthe crude product was purified by preparative HPLC

出典と根拠

ORDレコード
ord-e28363ed474a465989559d9c52a07b63
出典データセット
uspto-grants-2013_06
特許番号
US08470820B2

反応ノート

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