(E)-3-(4-chloro-3-hydroxy-phenyl)-acrylic acid ethyl ester → HCID 21246560、化合物
反応式
C([O:3][C:4](=[O:15])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([OH:14])[CH:8]=1)C>Cl.C(O)(=O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7](/[CH:6]=[CH:5]/[C:4]([OH:15])=[O:3])=[CH:8][C:9]=1[OH:14]参加物
4
反応条件
- 温度
- 85 °C
実験手順
(E)-3-(4-Chloro-3-hydroxy-phenyl)-acrylic acid ethyl ester (1.45 g, 6.4 mmol) was dissolved in a mixture of 6N HCl (8 ml) and acetic acid (8 ml) and heated at 85° C. for 3.5 hrs. Solvents were evaporated, giving 1.23 g of (E)-3-(4-chloro-3-hydroxy-phenyl)-acrylic acid as a light yellow solid.
後処理
- customSolvents were evaporated
出典と根拠
- ORDレコード
- ord-6c13a48f25aa428faf1c6d06869e548d
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08470831B2
反応ノート
読み込み中…