化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1-Phenylpyrazol-5-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate | HCID 85270 | — |
| 生成物 | 1-Phenylpyrazol-5-ylamine | HCID 70006 | 94% |
反応手順
5-Amino-4-carbethoxy-1-phenylpyrazole (1 eq.) was dissolved in 36% HCl solution (30 eq.) and the reaction mixture was stirred under reflux for overnight. The mixture was cooled, poured onto ice and made basic with NH4OH. The mixture was extracted with DCM (×3). The combined organic fractions were washed with brine, dried (Na2SO4), and the solvent was evaporated under reduced pressure to obtain the product as pale yellow oil in 94% yield. MS (ES+) C9H9N3 requires 159, found: 160 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08470823B2 |
| 出典データセット | uspto-grants-2013_06 |
| ORD ID | ord-e2f183bfde9840139d413b9b940b96d3 |
| 出典メモ | uspto-grants-2013_06 |