関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Chloro-4-fluorobenzaldehyde | HCID 145024 | — |
| 反応物 | Sodium methanesulfinate | HCID 2733271 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2-Chloro-4-(methylsulfonyl)benzaldehyde | HCID 2761084 | — |
反応手順
A suspension of 2-chloro-4-fluorobenzaldehyde (24.9 g, 0.16 mol) and dry sodium methanesulfinate (17.9 g, 0.175 mmol) in dry DMSO (60 ml) is stirred at 90° C. overnight. The reaction mixture is allowed to cool to room temperature and then poured onto ice-water (400 ml). The resulting precipitated is collected by filtration and dried under high vacuum to yield the titled compound as a yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08470848B2 |
|---|
| 出典データセット | uspto-grants-2013_06 |
|---|
| ORD ID | ord-98ea714a4cc0460797db4ad8ce7cef09 |
|---|
| 出典メモ | uspto-grants-2013_06 |
|---|
