1-(Bromomethyl)-3-chlorobenzene → 1-(3-Chlorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide
反応式
[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1>CN(C)C=O>[BrH:11].[Cl:19][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[CH2:12][N:10]1[CH:9]=[CH:8][CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2]1=[NH:1]参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of 2-aminonicotinamide (0.1 g) in N,N-dimethylformamide (3 ml) was added 1-(bromomethyl)-3-chlorobenzene (0.3 g), and the mixture was stirred at 80° C. for 15 hr. The precipitated crystals were collected by filtration and washed with ethyl acetate to give the title compound (90 mg).
後処理
- filtrationThe precipitated crystals were collected by filtration
- washwashed with ethyl acetate
出典と根拠
- ORDレコード
- ord-3f284f2d52a6409190995c17568b0513
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08470859B2
反応ノート
読み込み中…