1-(Bromomethyl)-3-chlorobenzene → 1-(3-Chlorobenzyl)-2-imino-5-methyl-1,2-dihydropyridine-3-carboxamide hydrobromide

HRID 1260860ノート

反応式

HRID 1260860 の反応式
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][Br:17]>CN(C)C=O.C(OCC)(=O)C>[BrH:17].[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][N:10]1[CH:9]=[C:8]([CH3:11])[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2]1=[NH:1]

参加物

5

反応物 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 668782802-Amino-5-methylnicotinamide

生成物 1

HCID 686617751-(3-Chlorobenzyl)-2-imino-5-methyl-1,2-dihydropyridine-3-carboxamide hydrobromide収率 42.4%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
100 °C

実験手順

To a solution of 2-amino-5-methylnicotinamide (0.15 g) in N,N-dimethylformamide (3 ml) was added 3-chlorobenzylbromide (0.31 g), and the mixture was stirred at 100° C. for 6 hr. The reaction mixture was diluted with ethyl acetate. The precipitate was collected by filtration and washed with ethyl acetate. The obtained precipitate was recrystallized from methanol-ethyl acetate to give the title compound (0.15 g).

後処理

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with ethyl acetate
  3. customThe obtained precipitate was recrystallized from methanol-ethyl acetate

出典と根拠

ORDレコード
ord-3bd7219d438444a5bbed78ca8a8add6b
出典データセット
uspto-grants-2013_06
特許番号
US08470859B2

反応ノート

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