2-(Bromomethyl)-1-fluoro-4-methylbenzene → 5-Chloro-1-(2-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

反応式

[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][CH2:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=1[F:21]>>[BrH:12].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=2[F:21])[CH:9]=1

参加物

反応物 2

HCID 177508002-(Bromomethyl)-1-fluoro-4-methylbenzene

HCID 668768832-Amino-5-chloronicotinamide

生成物 1

HCID 686623825-Chloro-1-(2-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

実験手順

According to the method of Example 172, 2-amino-5-chloronicotinamide was reacted with 2-(bromomethyl)-1-fluoro-4-methylbenzene to give the title compound.

出典と根拠

ORDレコード: ord-3caa1207416548c7a219f362bd4c0168
出典データセット: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08470859B2

反応ノート

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