1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid → N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxamide

HRID 1260956ノート

反応式

HRID 1260956 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([NH:18][CH3:19])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:28][C:29]([F:45])([F:44])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]1[CH:40]=[CH:39][N:38]=[C:37]1[C:41]([OH:43])=O>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:19])[C:41]([C:37]3[N:36]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[C:29]([F:28])([F:45])[F:44])[CH:40]=[CH:39][N:38]=3)=[O:43])[C@H:14]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:13]2)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 27607571-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acidHCID 57741761(3R*,4R*)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)-N-methylpiperidin-4-amine

生成物 1

HCID 68935740N-[(3R,4R)-1-[(1-acetylpiperidin-4-yl)carbonyl]-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methyl-1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxamide

実験手順

Using the compound obtained in Example 78 and 1-[2-(trifluoromethyl)phenyl]-1H-imidazole-2-carboxylic acid, and by the reaction and purification in the same manner as in Example 3, the title compound was obtained.

後処理

  1. customby the reaction and purification in the same manner as in Example 3

出典と根拠

ORDレコード
ord-3bc8e19e926648eaa5b4d0e58ac2b758
出典データセット
uspto-grants-2013_06
特許番号
US08470816B2

反応ノート

読み込み中…