1-Glycoloylpiperidine-4-carboxylic acid → 5-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(hydroxyacetyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylpyridine-2-carboxamide

HRID 1260989ノート

反応式

HRID 1260989 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]([C@@H:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[CH3:11])=[O:9])=[N:6][CH:7]=1.[OH:26][CH2:27][C:28]([N:30]1[CH2:35][CH2:34][CH:33]([C:36](O)=[O:37])[CH2:32][CH2:31]1)=[O:29]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]([C@@H:12]2[CH2:17][CH2:16][N:15]([C:36]([CH:33]3[CH2:34][CH2:35][N:30]([C:28](=[O:29])[CH2:27][OH:26])[CH2:31][CH2:32]3)=[O:37])[CH2:14][C@H:13]2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[CH3:11])=[O:9])=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 242848391-Glycoloylpiperidine-4-carboxylic acidHCID 866314225-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylpyridine-2-carboxamide

生成物 1

HCID 689321915-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(hydroxyacetyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylpyridine-2-carboxamide

実験手順

Using the compound obtained in step 1 and 1-(hydroxyacetyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 265, the title compound was obtained.

後処理

  1. customby the reaction and purification in the same manner as in Example 265

出典と根拠

ORDレコード
ord-858049707c254f069489ed1c19886aff
出典データセット
uspto-grants-2013_06
特許番号
US08470816B2

反応ノート

読み込み中…