HCID 178457071、化合物 → Allyl-(1-pyridin-3-yl-allyl)-amine
反応式
[CH:1]([Mg]Cl)=[CH2:2].[N:5]1[CH:10]=[CH:9][CH:8]=[C:7](/[CH:11]=[N:12]/[CH2:13][CH:14]=[CH2:15])[CH:6]=1>>[CH2:13]([NH:12][CH:11]([C:7]1[CH:6]=[N:5][CH:10]=[CH:9][CH:8]=1)[CH:1]=[CH2:2])[CH:14]=[CH2:15]参加物
3
実験手順
According to Example 2, vinyl magnesium chloride (1.00 M in THF, 1.10 mL; 1.10 mmol; 1.10 equiv) was reacted with N-[(E)-3-pyridinylmethylidene]-2-propen-1-amine (11) (146 mg; 1.00 mmol) in the presence of LaCl3.2LiCl (0.33 M; 0.30 mL, 0.10 mmol, 0.10 equiv) at room temperature for 1 h. Column chromatographical purification afforded the desired product 12 as colorless oil (151 mg, 87%). The analytical data were found to be in accordance with the literature data.
後処理
- customColumn chromatographical purification
出典と根拠
- ORDレコード
- ord-877b066ac31f4db2a041f8812d0bec57
- 出典データセット
- uspto-grants-2013_06
- 特許番号
- US08470982B2
反応ノート
読み込み中…