HCID 59846206、化合物 → Methyl 4-(3-(4-chloro-2-(phenylamino)phenyl)-3-oxopropyl)benzoate
反応式
[CH3:1][O:2][C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:13])=[CH:6][CH:5]=1>C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:28])[C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:13])=[CH:8][CH:9]=1参加物
3
実験手順
A 500 mL round-bottomed flask equipped with a stirrer was charged with 4-[(E)-3-(4-chloro-2-phenylamino-phenyl)-3-oxo-propenyl]-benzoic acid methyl ester (5.5 g, 14.0 mmol) and ethyl acetate (100 mL). The resulting mixture was stirred under a hydrogen atmosphere for 1 h. At this time, the catalyst was removed by filtration and washed with ethyl acetate. The filtrates were concentrated in vacuo to afford 4-[3-(4-chloro-2-phenylamino-phenyl)-3-oxo-propyl]-benzoic acid methyl ester (5.5 g, 99.5%) as a gummy solid. This material was used without further purification.